Influence of breast feeding on the clinical features of salt-losing congenital adrenal hyperplasia.

110/60 mmHg and pulse rate 130/min and regular. Results of laboratory investigations were normal. S. flexneri type 2a was later isolated from the stool. Treatment was started with ampicillin 250 mg every 8 hours orally. Six hours after admission she had a grand mal seizure and shortly thereafter became apnoeic and unresponsive to noxious stimulation. The pupils were widely dilated (6 mm) and fixed, and there was no response to caloric or oculovestibular testing. Cerebrospinal fluid analysis was normal. Computerised tomography scan of the brain showed diffuse areas of low density throughout the brain. Five hours later the electroencephalogram was isoelectric. At necropsy the entire bowel was congested and the colonic mucosa was infiltrated by polymorphonuclear cells. Extensive necrosis was present throughout the brain and coning of the cerebellum was noted. The remainder of the organs seemed normal.